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CASE20191012_003
CORONARY - Stents (bare-metal, drug-eluting)
A Patient with Repeated In-Stent Complications After Implantation of 3rd Generation DES
Kazumasa Ikeda1, Nobuhiro Tanaka2, Yohei Hokama2, Kunihiro Sakoda2
Hachiouji Medical Center, Japan1, Tokyo Medical University Hachioji Medical Center, Japan2,
[Clinical Information]
- Patient initials or identifier number:
E.M.
-Relevant clinical history and physical exam:
A-58-year-old man (had a history of hypertension and smoking) underwent PtCr-EES implantation in LAD #7 for stable angina 3 years ago. Followup angiography a year after PCI demonstrated occlusion of the stent, and he underwent balloon angioplasty. CAG a year after POBA showed occlusion again, and he implanted CoCr-SES. He was hospitalized in order to undergo 4th angiography. There were no abnormal findings on physical exam.
-Relevant test results prior to catheterization:
The troponin level was not elevated in laboratory test.Electrocardiography showed normal sinus rhythm and negative T wave in leads aVL.Echocardiography revealed hypokinesis of anterior of the left ventricule, and myocardial ischemia was proved in the same regions by SPECT.

- Relevant catheterization findings:
At 12 months after CoCr-SES implantation (at 38 months after PtCr-EES implantation) angiography revealed severe stenosis at proximal and distal edge of CoCr-SES. In addition, per-stent contrast staining (PSS) which indicates an inflammatory reaction was also recognized. This was his third time complication re-lated with stent, therefore we perform CABG.
Relevant catheterization findings.mp4
[Interventional Management]
- Procedural step:
In the first angiography, there was a severe bifurcation lesion in the mid of LAD, involving the ostium of the diagonal brunch. We implanted PtCr-EES (2.75mm in diameter; 20mm in length) inLAD #7 (video1). IVUS after stent implantation demonstrated well-expanded stent struts without evidence of incomplete stent apposition.Follow-up angiography at 12 months after first stenting demonstrated total occlusion of the stent and IVUS revealed extreme positive remodeling of the vessel at the stent site compared with previous imaging.At that time, we cared about metal allergy and completed the procedure only by using noncompliant balloon (video2). After the procedure, it had revealed that the patient had no metal allergy.In spite of it, about 12 months after the second procedure, the stent site was totally occluded again. We had confirmed he had no metal allergy, thus we implanted new DES, CoCr-SES (2.25mm in diameter; 18mm in length and 3.0mm-30mm) (video3).The final angiography was performed 12 months after the third procedure, and it revealed severe stenosis at proximal and distal edge of CoCr-SES. In addition, peri-stent contrast staining (PSS) which indicates an inflammatory reaction was also recognized. This was his third time complication related wi-th stent, therefore we perform CABG.
TCTAP2020 video1.mp4
TCTAP 2020 video2.mp4
TCTAP 2020 video 3.mp4
- Case Summary:
Although PCI is an effective therapy, but there still remain, rarely a problem of in-stent restenosis and stent thrombosis.We confirmed that our patient did not show a finding of metal allergy, but he recurred in-stent complication several times.We think he has a hypersensitivity to something of components of stent (metal, polymer or drugs), but we couldn¡¯t specify what it was.Our findings indicate that careful long term follow up remains important even after placement of 3rd generation DES.
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