Results for 710 patients who underwent PCI procedures are reported. Of these, 85% (n=604) of cases utilized the prescribed OCT workflow in at least 1 lesion, for a total of 652 (75%) evaluable lesions. Overall, 88% of lesion-level procedural decision-making was impacted with OCT (83% pre-PCI and 31% post-PCI). Compared with angiography alone, pre-PCI OCT resulted in changes in the operator assessment of lesions morphology (48%); treatment type (8.1%); type of vessel preparation (28%), stent diameter (38%), and stent length (36%) (Figure 1). Post-PCI OCT guidance identified underexpansion enabling targeted optimization in 25% of lesions. There was no significant difference in clinical decision making changes in diagnosis, treatment, and optimization among physician experience groups (Figure 2).