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ABS20191115_0013
Pharmacology/Pharmacotherapy
A Prospective Observational Study on Traditional Chinese Medicine Treatment of Patients After Percutaneous Coronary Intervention
Siyu Yan1, Lihong Ma1
Fuwai Hospital, China1
Background:
To systematically evaluate the impact of traditional Chinese medicine (TCM) on cardiovascular composite endpoint events in patients with coronary heart disease after percutaneous coronary intervention (PCI), so as to provide evidence-based basis for the long-term efficacy.
Methods:
This study adopts prospective, observational registration study method, selected patients diagnosed with coronary heart disease and accepted PCI therapy in Fuwai hospital Chinese academy of medical sciences from September 2016 to August 2017, collected their baseline data and follow-up 2 years. According to actual treatment strategies, patients can be divided into TCM plus conventional treatment group and conventional treatment alone group, established cox regression model to evaluate the efficacy of the two groups. The primary endpoint was cardiovascular composite endpoint events in two years, including all-cause death, revascularization and myocardial infarction (MI). The secondary endpoint was stroke.
Results:
A total of 5942 patients with coronary heart disease after PCI were enrolled in this study, among which 5471 patients were had followed up, 2944 patients (53.8%) in conventional treatment alone group and 2527 patients (46.2%) in TCM plus conventional treatment group. Cox regression analysis showed that, compared with conventional treatment alone group, TCM plus conventional treatment group could reduce the risk of cardiovascular composite endpoint events by 23.8% (HR,0.762; 95%CI,0.661-0.879; P<0.001), reduce the risk of re-PCI by 15.8% (HR,0.842; 95%CI,0.714-0.993; P=0.040), and reduced the risk of all-cause death by 90.1% (HR,0.099; 95%CI,0.048-0.205; P<0.001). The incidence of stroke was 0.9% in TCM plus conventional treatment group and 0.8% in conventional treatment group (HR,1.111; 95%CI,0.630-1.960; P=0.715).
Conclusion:
The results of the study suggested that patients treated with traditional Chinese medicine on the basis of conventional western medicine can reduce the incidence of cardiovascular composite end point events, relieve the patient's clinical symptoms and gain more benefits than those treated with western medicine alone, especially on re-PCI and all-cause death.
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