Lots of interesting abstracts and cases were submitted for TCTAP 2025. Below are the accepted ones after a thorough review by our official reviewers. Don’t miss the opportunity to expand your knowledge and interact with authors as well as virtual participants by sharing your opinion in the comment section!
TCTAP A-004
Regional Variations in Sex-Based Outcomes of Transcatheter Aortic Valve Replacement: A Meta-Analysis of 657,850 Patients
By Sofian Zreigh, Ahmad Al Othman, Mohammed Benhammou, Abubaker Salahudin Mukhlif Al-Allawee, Walid Guerguer, Ashraf Haidarah, Serag Almzainy, Qasim Ezeddin Shawesh, Saber Khalid, Mohamedhen Vall Nounou, Rafeeek Elmezayen, Mohammad Alzu’bi, Maram Abuajamieh, Muhiddin Drvis, Muhammed Elhadi
Presenter
Sofian Zreigh
Authors
Sofian Zreigh1, Ahmad Al Othman2, Mohammed Benhammou3, Abubaker Salahudin Mukhlif Al-Allawee4, Walid Guerguer5, Ashraf Haidarah6, Serag Almzainy7, Qasim Ezeddin Shawesh7, Saber Khalid8, Mohamedhen Vall Nounou9, Rafeeek Elmezayen10, Mohammad Alzu’bi11, Maram Abuajamieh12, Muhiddin Drvis1, Muhammed Elhadi7
Affiliation
Ankara Yildirim Beyazit University, Turkey1, Near East University, Cyprus2, University of Oran 1, Algeria3, University of Fallujah, Iraq4, University of Algiers 1, Algeria5, West China Hospital, China6, University of Tripoli, Libya7, Benghazi University, Libya8, University of Nouakchott Al Aasriya, Mauritania9, Kafr-Elsheikh University, Egypt10, The Hashemite University, Jordan11, Cairo University, Egypt12
View Study Report
TCTAP A-004
Complex TAVR
Regional Variations in Sex-Based Outcomes of Transcatheter Aortic Valve Replacement: A Meta-Analysis of 657,850 Patients
Sofian Zreigh1, Ahmad Al Othman2, Mohammed Benhammou3, Abubaker Salahudin Mukhlif Al-Allawee4, Walid Guerguer5, Ashraf Haidarah6, Serag Almzainy7, Qasim Ezeddin Shawesh7, Saber Khalid8, Mohamedhen Vall Nounou9, Rafeeek Elmezayen10, Mohammad Alzu’bi11, Maram Abuajamieh12, Muhiddin Drvis1, Muhammed Elhadi7
Ankara Yildirim Beyazit University, Turkey1, Near East University, Cyprus2, University of Oran 1, Algeria3, University of Fallujah, Iraq4, University of Algiers 1, Algeria5, West China Hospital, China6, University of Tripoli, Libya7, Benghazi University, Libya8, University of Nouakchott Al Aasriya, Mauritania9, Kafr-Elsheikh University, Egypt10, The Hashemite University, Jordan11, Cairo University, Egypt12
Background
Aortic stenosis (AS) is a common valvular heart disease, with an estimated prevalence ranging from 3% to 10%, affecting females and males equally. Transcatheter aortic valve replacement (TAVR) has emerged as a widely adopted treatment in AS, demonstrating efficacy across various risk profiles. However, the impact of sex differences on TAVR outcomes remains a topic of debate, with a notable gap in literature addressing these variations across diverse geographical regions. This meta-analysis seeks to investigate sex-based differences in TAVR outcomes and evaluate their consistency across regions.
Methods
A comprehensive literature search was conducted across Scopus, Cochrane Library, PubMed, and Web of Science databases up to October 2024. Studies comparing TAVR outcomes between males and females were included and grouped by region based on available data: Europe, Asia, and North America. A random-effects meta-analysis was performed to calculate the risk ratio (RR) and mean differences (MD) with 95% confidence intervals (CI) for the outcomes, and heterogeneity was assessed using the I² statistic. Statistical analysis was conducted using R Studio version 4.3.2 with the 'meta' package.
Results
Our analysis of 58 studies, including657,850 patients (351,927 males and 305,923 females), revealed distinctgender-based outcomes across continents. In-hospital mortality demonstrated ahigher risk for females in North America (RR 1.36, 95% CI 1.18–1.58) but showedno difference in Europe (RR 1.00, 95% CI 0.93–1.08); no studies in Asiaevaluated this outcome. Overall, the analysis indicated elevated in-hospitalmortality among females (RR 1.16, 95% CI 1.02–1.32). One-year mortality waslower for females in Europe (RR 0.84, 95% CI 0.79–0.89) and North America (RR0.93, 95% CI 0.88–0.98) but no significant difference in Asia (RR 0.88, 95% CI0.59–1.30), with lower overall female mortality (RR 0.87, 95% CI 0.82–0.93).Regarding secondary outcomes, females showed a significantly higher risk ofmajor vascular complications in Europe (RR 1.53, 95% CI 1.41–1.67) and NorthAmerica (RR 1.88, 95% CI 1.72–2.05), but not in Asia (RR 0.83, 95% CI0.27–2.53), with an overall increased risk (RR 1.66, 95% CI 1.54–1.80). Similarly,females had a higher risk of major bleeding in Europe (RR 1.22, 95% CI1.02–1.45) and North America (RR 1.31, 95% CI 1.29–1.34), but not in Asia (RR1.10, 95% CI 0.47–2.56), with an overall increased risk (RR 1.28, 95% CI1.16–1.41). In-hospital stroke risk was higher for females across allcontinents (RR 1.25, 95% CI 1.15–1.37), while 30-day stroke was significantonly in North America (RR 1.32, 95% CI 1.00–1.73), with overall analysisshowing increased risk (RR 1.24, 95% CI 1.07–1.47). One-year stroke showedsignificance only in North America (RR 1.33, 95% CI 1.17–1.52), with overallanalysis being non-significant (RR 1.19, 95% CI 0.99–1.43). Acute kidney injurydemonstrated lower risk for females in North America (RR 0.91, 95% CI0.83–0.97) but not in Europe or Asia, though overall analysis indicated lowerfemale risk (RR 0.91, 95% CI 0.86–0.97). Myocardial infarction showed nosignificant differences across continents (RR 1.05, 95% CI 0.95–1.16).
Conclusion
Our meta-analysis highlights regional and sex-baseddifferences in TAVR outcomes. These findings suggest that regional factors,including healthcare systems and patient demographics, may contribute toobserved disparities in outcomes between sexes in TAVR outcomes. Furtherresearch is needed to better understand these differences and optimize care forpatients of all sexes across diverse regions.