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April 27 (Fri.), 2012
Lessons from Two Late-Breaking Clinical Trials
Cilostazol in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention
Multicenter Randomized Trial Evaluating the Efficacy of Cilostazol on Inhibition of Platelet Aggregation, Inflammation and Myonecrosis in ACS Patients Undergoing PCI: the Results of ACCEL-LOADING-ACS (ACCELerated nhibition of Platelet Aggregation, Inflammation and Myonecrosis by Adjunctive Cilostazol LOADING in Patients with Acute Coronary Syndrome) Trial

Young-Hoon Jeong, MD

Cilostazol pretreatment reduced platelet activation, inflammation and ischemia-reperfusion injury; these benefits have not been tested in a randomized study. Young-Hoon Jeong, MD, from Gyeongsang National University Hospital, Korea and his colleagues evaluated the efficacy and safety of cilostazol pretreatment in ACS patients. Dr. Young-Hoon Jeong and colleagues randomized Asian patients with non ST-segment elevation (NSTE)-ACS to aspirin and clopidogrel (prePCI 600 mg loading + 75 mg/d) (DOUBLE=111) or adjunctive cilostazol (prePCI 200 mg loading +100 mg bid) to standard therapy (TRIPLE=107). Primary endpoint was 30d incidence of CV death, MI, or TVR. CK-MB and troponin I were measured before.......
Catheter-Based Renal Sympathetic Denervation

The 17th ANGIOPLASTY SUMMIT 2012-TCTAP had a program about the latest technical and clinical investment and case-based learning by live case presentation about catheter-based renal sympathetic denervation. On Thursday morning, at 11:30 AM in the Endovascular Arena, ¡°Live Case Presentation for Renal Denervation¡± was held. In addition, at 7:00 AM, Wednesday, in the Tutorial Arena, there was a ¡°Medtronic AP Morning Session: DES + ARDIAN (Renal Denervation)¡± covering
topics ranging from patient selection to technique and tips of catheter-based renal denervation.
Resistant hypertension or therapy-refractory hypertension is defined as uncontrolled blood pressure despite the use of optimal doses of more than three antihypertensive drugs(including a diuretic). Patients with therapy-refractory hypertension are at particular risk for cardiovascular events. Despite numerous antihypertensive drugs, hypertension remains resistant in a considerable number of patients, thus creating the need for alternative strategies, including interventional approaches. Recently, catheter-based renal sympathetic denervation has been shown.....

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