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The most prominent faculty of the ANGIOPLASTY SUMMIT-TCTAP 2012 will share their experience and opinion in the interventional vascular field.

Antonio Colombo, MD
EMO Centro Cuore Columbus, San Raffaele Hospital, Italy

Q > 1. We want to learn how to do bifurcation stenting successfully. Please tell us your strategy for bifurcation stenting.
    (1) What are your criteria for planning 2-stents implantation in bifurcation lesion?
    (2) Do you think IVUS examination is mandatory in bifurcation coronary stenting?
  2. To reduce stent thrombosis rate, what can we do during procedure? Please tell us your treatment strategy in real practice.
   

William F. Fearon, MD
Stanford University Medicine Center, USA

Q > 1. FAME2 study was halted the enrollment after only 2/3 of the planned patients were included. Would you tell us how can we interpret this result? What do you expect the result of 'ISCHEMIA' study?
  2. Would you explain about functional Syntax score? Please tell us the clinical meaning of this score.
  3. In real practice, It is not easy to measure FFR for the ACS patients. Would you tell us what is the role and benefit of FFR in the unstable angina or NSTEMI patients?
   

William A. Gray, MD
New York-Presbyterian Hospital, Columbia University Medical Center, USA

Q > 1. Would you explain design and result of ACTIVE trial? What is the clinical impact of this trial?
  2. Would you explain the different result between CREST trial and several mega-trials like SPACE, ICSS?
  3. What is the strong point of CAS over CEA? To improve the CAS outcome, where should we focus on?
   

Eberhard Grube, MD
Elisabeth Hospital Heart Center Rhein-Ruhr, France

Q > 1. What is the special indication of valve-in-valve TAVR?
  2. Please tell us the pro and cons of CoreValve compared with Edward valve in TAVR?
  3. Who will be the included as potential candidates of TAVR in the future?
   

Ziyad M. Hijazi, MD
Rush University Medical Center, USA

Q > 1. What is the potential limitation of current ASD devices?
  2. Please tell us your tips to improve success rate in very big ASDs.
   

David Richard Holmes, MD
Mayo Clinic, USA

Q > 1. Would you tell us briefly about the most important message of 'PROTECT AF' trial?
  2. The results of recent clinical studies for multivessel disease are discouraging to interventional cardiologist. Do you think we have to change our mind in selecting treatment option?
  3. Please tell us how fatal the procedure related complications are during Watchman device inplantation.
   

Michael R. Jaff, MD
Massachusetts General Hospital, USA

Q > 1. We do not have the answer for the optimal treatment strategy of renovascular hypertension with renal artery stenosis. What is your treatment strategy for renal artery stenosis?
  2. Would you tell us the design and current status of CORAL trial? What can we learn from CORAL trial?
  3. For preventing rupture, we treat AAA with open surgical repair or endovascular therapy. When can we treat the patients with medication and follow-up instead of endovascular therapy?
  4. Please tell us optimal treatment strategy for the asymptomatic patients with carotid artery disease.
   

David E. Kandzari, MD
Piedmont Heart Institute, USA

Q > 1. Please tell us the rationale behind investigating renal denervation with RF ablation for the treatment of refractory hypertension.
  2. Would you briefly explain the result of Simplicity-HTN1 and 2 trials? And also, could you briefly introduce the ongoing clinical trial SYMPLICITY HTN-3?
  3. Currently, there are many efforts to extend the indication of renal denervation to the patient with sleep apnea, heart failure and chronic kidney disease. Would you explain how renal denervation works on sleep apnea, CHF and CKD?
   

Spencer B. King III, MD
Saint Joseph's Heart and Vascular Institute, USA

Q > 1. There have been long-term debates regarding potential benefit of thrombus aspiration during primary PCI in STEMI patients?
How about your opinion among routing aspiration vs. selective aspiration vs. no aspiration?
  2. Could you comment your opinion regarding mostly optimal anticoagulation for ACS patients with large thrombus burden?
  3. As the Editor-in-chief of the Major Cardiovascular Journal, which issues or topics should be more answered from future trials in this field (i.e., STEMI urgent PCI procedures)?
   

Martin B. Leon, MD
NewYork-Presbyterian Hospital, CUMC, USA

Q > 1. In this year ACC meeting, long-term results of PARTNER Trial were presented. Could you briefly summarize the potential clinical impact on clinical practice?
  2. Please tell us what are the current limitations of TAVR devices? What is requirement for the future TAVR system?
  3. Would you explain what 'Dedicated LM stent' is? What is the reason that 'Dedicated LM stent' is needed?
   

Akiko Maehara, MD
Cardiovascular Research Foundation, USA

Q > 1. With VH-IVUS and OCT images, What is your perspectives on 'temporal stability of the plaques'? Are there any predictors for plaque stabilization?
  2. Are there any difference in plaque distribution and composition between Left Main bifurcation and non Left Main Bifurcations? What would be clinical implication of the observations in terms of treatment strategy and PCI outcomes for bifurcation lesions?
  3. (1) Do you think if the criteria based on FFR>0.80 would be safe for deferral? If it is not enough, what do you consider to decide to treat or not to treat?
    (2) Would you address the role of IVUS compared to FFR during LM PCI?
  4. In a practical point of view, what do you think of clinical utility of OCT during the PCI?
   

Roxana Mehran, MD
Mount Sinai Hospital, USA

Q > 1. We have many available anti-platelet agents up to now. However it is not easy to optimize antiplatelet therapy according to the each patient characteristic. Would you give us practical guideline for the personalized medical treatment?
  2. Bleeding is important factor can influence on the mortality as much as ischemia. Would you tell us the risk factors for Bleeding based on your study? Also could you tell us the clinical impact of the bleeding risk score model?
  3. Currently we are conducting mach kind of global clinical trials. Would you tell us what is advantages and disadvantages of global clinical trial? To improve the quality of global clinical trial, what should we more focus on?
   

Gary S. Mintz, MD
Cardiovascular Research Foundation, USA

Q > 1. We have many sort of imaging modalities to evaluate coronary lesions (IVUS, OCT, NIRS and FFR.., What is your strategy to select the imaging modalities to get optimal information?
  2. Please explain how to improve the appropriate usage and interpretation of the imaging modalities in the cath-lab.
  3. Would you address what are the key messages from the PROSPECT trial? And, what would be the perspectives of future imaging study?
   

Nico Pijls, MD
Cathrina Hospital, Netherlands

Q > 1. Please explain the concept of 'functional complete revascularization'. What is clinical impact of 'functional complete revascularization'?
  2. What are your perspectives on the treatment ofmulti-vessel coronary artery disease? Would you explain what the difference between SYNTAX and FAME trial is?
  3. FAME trial has changed practical pattern to FFR-guided PCI and many studies with FFR are ongoing now. What do you expect future direction of functional angioplasty with FFR?
   

Horst Sievert, MD
CardioVascular Center Frankfurt, Germany

Q > 1. Can you suppose how many hypertensive patients will be the potential candidates of renal denervation?
  2. New antithrombotic drugs are recently approved for prevention of stroke in atrial fibrillation patients. Do you think what will be the future role of LAA closure device?
  3. Renal denervation is currently contraindicated for renal failure patients. Is there a possibility to expand the indication of renal denervation to those patients?
   

Gregg W. Stone, MD
Columbia University Medical Center, Cardiovascular Research Foundation, USA

Q > 1. The results of MAIN-COMPARE, SYNTAX, and PRECOMBAT have already been reported. What is the additional important question in the EXCEL trial?
  2. Based on the results of ACUITY, HORIZON and INFUSE-AMI trials, how do you recommend treating high-risk ACS patients using bivalirudin and GP IIb/IIIa inhibitors?
  3. Please provide your daily practice in deciding the treatment option between CABG and PCI for multivessel disease. Do you think the SYNTAX score should be a primary factor for our decision-making in all patients?
   

Corrado Tamburino, MD
Ferrarotto Hospital University of Catania, Italy

Q > 1. Would you briefly explain the good points and bad points of the current SYNTAX score for LM revascularization?
  2. What is the best or most predictive risk score for outcomes from the NERS, CSS, GRC etc?
  3. Recently you presented the result of 'Italian Core valve registry'. What can we learn from the result of the registry?
  4. In routine practice, there are several patients having combined significant coronary artery disease and severe AS, but not eligibile open heart surgery?
In these patients, which procedure would be first? Would you tell us when the appropriate time to do PCI is?
   

Renu Virmani, MD
CV Path Institute, Inc., USA

Q > 1. As pathologic point of view, would you tell us what structural features predict plaque vulnerability?
  2. In clinical practice, it is not easy to define how big necrotic core or how thin fibrous cap is vulnerable plaque.
Based on your pathologic studies, would you give us your perspectives on this matter?
  3. CV path constantly has published about pathologic findings in relation to atherothrombotic disease.
Would you explain the mechanism of plaque progression? Can you tell us what will be the next target for new drug to stabilize the plaque?
   

Stephan Windecker, MD
Swiss Cardiovascular Center, Switzerland

Q > 1. Recently, long-term four-year results from the LEADERS trial was reported and published. Would you brief introduce the key findings and explain the clinical impact on our future clinical practice?
  2. Would you briefly explain the future scenario of upcoming DES? What would be a winner after 5 years later among polymer free DES, biodegradable polyer DES, or bioabsorbable stent?
  3. Could you introduce your preference of specific DES according to clinical or lesion characteristics?
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