Myocardial Viability Assesed with Fluorodeoxyglucose Positron Emission Tomography as a Predictor of Cardiac Events In Patients with Acute Myocardial Infarction
1Fujimoto Hayasuzu Hospital, Miyazaki, Japan; 2Kagoshima University, Kagoshima, Japan
M. Tsurugida1, S. Hamasaki2, K. Kihara1, R. Arikawa1, K. Kusumoto1, C. Tei2
Background: To predict cardiac events by myocardial viability has not been reported in patients with acute myocardial infarction (AMI).The purpose of this study was to examine whether myocardial viability assessed by FDG-PET in acute phase of AMI can be a predictor of cardiac events in patients with AMI.
Methods: A total of 37 patients with reperfused first anteroseptal AMI were studied. FDG-PET was perfomed 2 weeks after PCI. Myocardial viability was assessed by viability score (VS). VS is derived from the mean value of score of FDG-PET uptake for infarcted areas with 5-point score system (no uptake=0, best uptake=4). We divided the patients into 2 groups; good viability group: VS> 2 (n=23), and good viability group: VS<2 (n=14). We examined whether there was a difference in the appearance of subsequent cardiac events (death, heart failure, CABG, re-PCI and serious arrhythmia) by Kaplan Meier method as an end point of the duration from the onset of AMI to the day of cardiac events.
Results: The average observation period was 692 days. The event free survivial rate assessed by Kaplan-Meier method was significantly (P=0.02) reduced in good viability group.
Conclusion: The present study demonstrated that the preservation of good myocardial viability can predict subsequent cardiac events. Therefore, it is clarified that myocardial viability assessed by FDG-PET is useful for assessing clinical outcome in patients with AMI.
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